seahorseCLL explorer
Drug responses
Genetic variants
Transcriptomics
Correlations between bioenergetic features and drug responses
Pre-filter by correlation tests
Coefficient cutoff
Raw P-value cutoff
"1" indicates the highest concentration;
"5" indicates the lowest concentration;
"1:5" indicates the averaged viability over all five concentrations;
"4:5" indicates the averaged viability over the lowest two concentrations.
Color samples by genetic feature
Select genetic feature
Methylation_Cluster
del13q14
IGHV.status
TP53
del11q22.3
del17p13
SF3B1
trisomy12
NOTCH1
ATM
BRAF
del8p12
gain8q24
Chromothripsis
EGR2
MED12
PCLO
gain2p25.3
del15q15.1
MGA
del9p21.3
del14q24.3
KRAS
MYD88
ACTN2
BIRC3
CPS1
FLRT2
KLHL6
RYR2
XPO1
ZC3H18
gain3q26
del6p21.2
del18p11.3
gain14q32
ABI3BP
COL6A5
CREBBP
DNAH17
DOCK11
FAM47A
FBXW7
FOXC1
IRF2BP2
KANK4
KDM6B
LAMA1
LRP1
NFKBIE
PRKD1
PRPF8
PRSS50
RASGRF2
RP11.766F14.2
SEMA4D
TRDN
VWF
del6q21
trisomy19
gain18q21
ADAMTS16
ANK2
BCOR
CADPS2
CARD11
CDH2
DCC
DSCAM
DST
FAT1
FAT4
HMCN1
KIAA1549L
MUC16
NCOR1
PBRM1
POT1
SGK1
SNAP91
TTN
UMODL1
NRAS
ADAMTS9
DDX3X
NRXN1
t.11.14.
Show samples without genetic data
Perform regression separately
Identify associations between bioenergetic features and genetic variants
Select a metabolic feature
basal.respiration
ATP.production
proton.leak
maximal.respiration
spare.respiratory.capacity
glycolysis
glycolytic.capacity
glycolytic.reserve
ECAR.OCR.ratio
OCR
ECAR
Filter results by raw or adjusted P values
Raw p value threshold
Adjusted P-value threshold
Show NA points
Explore the associations between CLL bioenergetics and gene expression
Select metabolic feature
basal.respiration
ATP.production
proton.leak
maximal.respiration
spare.respiratory.capacity
glycolysis
glycolytic.capacity
glycolytic.reserve
ECAR.OCR.ratio
OCR
ECAR
Select correlation method
pearson
spearman
Filter results by coefficients and p-values
Coefficient cutoff
Raw P-value cutoff
Enrichment analysis based on associations
Select geneset database
c2.cp.kegg.v5.1.symbols.gmt
c5.bp.v5.1.symbols.gmt
c6.all.v5.1.symbols.gmt
h.all.v5.1.symbols.gmt
Permutation number
Run GSEA (slow)
Run PAGE (fast)
Significance
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